Lyme is a town along the Connecticut River in Grafton County, New Hampshire, United States. The population was 1,745 as of the 2020 census. Lyme is home to the Chaffee Natural Conservation Area. The Dartmouth Skiway is in the eastern part of town, near the village of Lyme Center. The Appalachian Trail passes through the town's heavily woo…Lyme is a town along the Connecticut River in Grafton County, New Hampshire, United States. The population was 1,745 as of the 2020 census. Lyme is home to the Chaffee Natural Conservation Area. The Dartmouth Skiway is in the eastern part of town, near the village of Lyme Center. The Appalachian Trail passes through the town's heavily wooded eastern end.
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