Keiskammahoek is a town in the Eastern Cape Province, South Africa. From 1981 until the end of apartheid, the town was part of the Ciskei bantustan. Keiskammahoek is a small rural town that is situated some forty kilometers to the West of King William's Town in the Amahlathi Local Municipality, which is one of seven local municipalities that constitute the Amathole District Municipality, Eastern Cape. Keiskammahoek is surrounded by a number of villages and peri-urban settlements that support the town.