Santo Antão is the northwesternmost island of Cape Verde. At 785 km², it is the largest of the Barlavento Islands group, and the second largest island of Cape Verde. The nearest island is São Vicente to the southeast, separated by the sea channel Canal de São Vicente. Its population was 38,200 in mid 2019, making it the fourth most populous island of Cap…Santo Antão is the northwesternmost island of Cape Verde. At 785 km², it is the largest of the Barlavento Islands group, and the second largest island of Cape Verde. The nearest island is São Vicente to the southeast, separated by the sea channel Canal de São Vicente. Its population was 38,200 in mid 2019, making it the fourth most populous island of Cape Verde after Santiago, São Vicente and Sal. Its largest city is Porto Novo located on the southern coast.