The George R. Moscone Convention Center, popularly known as the Moscone Center, is the largest convention and exhibition complex in San Francisco, California, United States. The complex consists of three main halls spread out across three blocks and 87 acres in the South of Market neighborhood. The convention center originally opened in 1981. It is …The George R. Moscone Convention Center, popularly known as the Moscone Center, is the largest convention and exhibition complex in San Francisco, California, United States. The complex consists of three main halls spread out across three blocks and 87 acres in the South of Market neighborhood. The convention center originally opened in 1981. It is named after former San Francisco mayor George Moscone, who was assassinated in November 1978.