Tisch, 43, the Harvard-educated scion of a wealthy New York family, has worked for the city for 16 years, holding leadership roles in several agencies. As sanitation commissioner, she became TikTok famous when she declared in 2022, “The rats don’t run the city, we do.”

Ms. Tisch, a member of a prominent New York family who has held several positions in city government, will take over the nation’s largest police department.

NYC Mayor Eric Adams Wednesday named Sanitation Commissioner Jessica Tisch NYPD police commissioner — making her the second woman to serve in that role in the department’s 179-year history. Tisch, who will become the fourth person to lead the department during Adams’ tenure as mayor,