The San Francisco 49ers seem headed for their first missed playoff appearance since the 2020 season. After Sunday’s embarrassing 38-10 loss to the Packers, the injury-depleted Niners are buried in the standings and on the wrong side of several potentially key tiebreakers.

On Monday, San Francisco 49ers head coach Kyle Shanahan addressed wide receiver Deebo Samuel's underwhelming performances this season. Samuel has struggled to make a significant impact on the field, prompting questions about his role in the offense.

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert. If they get back the right players, the Bills will be facing a much tougher game against a playoff-level team desperate to keep their hopes alive.