Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game against the Bears with a sprained foot. While he’s considered day-to-day, San Francisco has a short week this week,

The San Francisco 49ers didn't anticipate getting down to a fourth-string running back, but they may find themselves in that situation entering a Week 15 showdown with the Los Angeles Rams on Thursday night at Levi's Stadium.

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the remainder of the regular season. Well, Guerendo suffered an injury of his own last week and is in danger of missing a Thursday night matchup with the Rams.