It wasn't until people on social media sounded the alarm about a distinct physical feature that Amy Schumer received her Cushing's syndrome diagnosis. The comedian, who first announced her condition in February 2024,

Cushing syndrome, which is also called Cushing’s syndrome, is a disorder that happens when your body makes too much of the stress hormone cortisol over a long period of time, according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Amy Schumer shared a selfie that she labeled "no filter" and "no filler" on Instagram Jan. 25, three days after giving insight into her Cushing syndrome diagnosis.