The top injuries to monitor. Plus, Jake Ciely's player rankings, weather reports and more fantasy and betting insights.

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

The San Francisco 49ers running back is questionable with a sprained foot, but per ESPN’s Adam Schefter: he “plans to play” ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

Our fantasy football buzz file, with contributions from our ESPN fantasy writers and our NFL Nation reporters, aims to ...

Three of last week’s top pickups — Isaac Guerendo (26.8 points), Adam Thielen (19.2) and Juwan Johnson (15) — won matchups in ...

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

If you're reading this, congratulations, I am assuming you made your Fantasy Football playoffs. Or, hi mom! Either way, ...

If the San Francisco 49ers want to defend their NFC West title, they must defeat the Los Angeles Rams in Week 15. However, the team enters Thursday Night Footba ...

Is Isaac Guerendo playing on "Thursday Night Football" or is he out? Is Isaac Guerendo injured or healthy for Week 15 TNF?

Guerendo rushed 16 times for 57 yards and brought in all four targets for 18 yards in the 49ers' 12-6 loss to the Rams on Thursday night. Guerendo overcame the foot sprain he'd suffered in the Week 14 ...