The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

The San Francisco 49ers are reportedly expected to lean on rookie running back Isaac Guerendo for the remainder of the 2024 ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey, at the premature end of a season that started late, too, waxed philosophical in a social media post on ...

McCaffrey's old backfield mate discussed the trials and tribulations of a season-ending injury on his podcast.

San Francisco 49ers running back Christian McCaffrey left Sunday night's contest versus the Buffalo Bills with what the team ...

Trevor Lawrence, Christian McCaffrey and Taysom Hill were among key players injured in Week 13 of the NFL season.

The 49ers star running back was ruled out of Sunday Night Football after suffering a knee injury in the first half against ...

In the 49ers' Week 13 game against the Buffalo Bills, McCaffrey suffered a PCL (posterior cruciate ligament) injury in his ...

Having suffered a knee injury that landed him on injured reserve during a snowy loss to the Bills on Sunday night, 49ers ...