The world No. 1 was thrown off by Siegemund's changes in pace and rhythm, but came through in three tight, tense sets.

The world No. 4 could not stage a comeback at his home Grand Slam, going out in round two for the second year in a row.

Sinner and Alcaraz have combined to win the last six Grand Slams -- and are pushing each other to new heights in the sport.

The second round of Wimbledon will get underway on Wednesday with a packed schedule of matches, including No. 2 seed Carlos Alcaraz taking the court.