Neither will be eliminated from playoff contention with a loss, but it would be devastating for their 2024 playoff chances. It would be a bigger problem for San Francisco given their current last place position in the NFC West,

Getting hurt the Sunday before a Thursday night game gave San Francisco 49ers fans plenty of reason to be skeptical about running back Isaac Guerendo playing against the Rams. But Guerendo is trying to play just four days after spraining his foot.

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian McCaffrey and Jordan Mason are both on injured reserve, leaving rookie Isaac Guerendo as the top back.