Disease” represents a return to form and a new step for Lady Gaga, featuring a dark electronic synth-pop production. Andrew Watt, Henry “Cirkut” Bell, and Gaga herself produced the song. The vocals of the chorus delve into a rock-like sound on the hook.

Lady Gaga released a stripped-back, guitar-driven rendition of "Disease," the lead single off her forthcoming album, dubbed LG7. In the "Disease (The Poison Live)" video, Gaga gives an emotive take on the dark electro-pop track with support from guitarist Tim Stewart at a Malibu recording studio.

The album is chaotic from a genre perspective,” teases Gaga of her seventh studio album—out in February. “Each song is an exercise in personal chaos—a way to deal with myself.”