At this point the past two seasons, the San Francisco 49ers were fighting for playoff positioning rather than their playoff ...

When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

SportsLine's model simulated Chicago Bears vs. San Francisco 49ers 10,000 times and made its Week 14 NFL picks, predictions ...

SportsLine simulated the NFL schedule 10,000 times and revealed optimal Week 14 Fantasy football rankings and sleepers to ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

The San Francisco 49ers are reportedly expected to lean on rookie running back Isaac Guerendo for the remainder of the 2024 ...

With Christian McCaffrey on the shelf, the 49ers will turn to RB Isaac Guerendo, and he will deliver in Week 14 against the Bears!

The San Francisco 49ers’ exceedingly deep backfield thinned out rapidly when running backs Christian McCaffrey and Jordan ...