In the absence of cures for multi-system inflammatory disease, therapies aim to dampen long-term inflammation, control symptoms and prevent tissue damage. Glucocorticoids (GC) are a key ...

Background Adverse childhood experiences (ACEs) have been linked to poorer adult health outcomes. ACEs may be a risk factor for heightened disease activity among Black American women living with ...

The landscape of therapeutic options for severe lupus nephritis (LN) is expanding. While the standard therapy is dual immunosuppression with glucocorticoid and either mycophenolate or cyclophosphamide ...

Objective This systematic review seeks to survey existing literature concerning systemic lupus erythematosus (SLE)-related thrombosis risk mechanisms within six pro-coagulable categories: ...

Background Single-cell RNA-sequencing (scRNA-seq) has been recently applied in systemic lupus erythematosus (SLE) to define distinct cellular composition and transcriptional signatures, greatly ...

Background Patients with SLE experience distressing fibromyalgia-like symptoms of fatigue, widespread pain, mood disturbance, and brain fog that negatively impact quality of life and are challenging ...

Background Low-dose IL-2 supplementation is a promising treatment of SLE. However, in most of current studies, lack of appropriate control groups lead to uncertainty on its efficacy. We conducted a ...

O37 Male gender, educational level, disease activity, prednisone daily dose and previous medical adherence are predictive of medical adherence in systemic lupus erythematosus patients – Data from the ...

Conclusion The SLE-DAS cut-off for SDA provides an accurate definition of SDA in SLE, with good discriminative power and consistent associations with worse HR-QoL. This SLE-DAS definition enhances ...

Background Modified immune cells (MICs) are mononuclear cells that gain immunosuppressive properties after incubation with the proliferation inhibitor mitomycin C. We showed that syngeneic MIC cell ...

Background There is clear evidence that clinical and laboratory features of systemic lupus erythematosus (SLE) can be present for many years prior to an individual fulfilling the full disease ...

Background Autoimmune and inflammatory diseases such as systemic lupus erythematous (SLE) affect tissues throughout the body. Alterations to inflammatory cell metabolism are often cited as a ...