Advancing the understanding of the tablet disintegration …
Apr 1, 2021 · Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental quality attribute of immediate release tablets.
Disintegrants used in pharmaceutical preparations
Sep 17, 2024 · Disintegrants are the most vital excipient in pharmaceutical formulations. They are also known as disintegrating agents or disintegrators. The process by which a solid oral dosage form such as a tablet breaks down into small particles is called disintegration.
Tablet Disintegration - an overview | ScienceDirect Topics
The mechanisms of tablet disintegration comprise swelling, strain recovery and wicking effect of the disintegrant. In swelling, tablet disintegration is due to the omni-directional enlargement of particles leading to the build-up of pressure and exertion of stress on the overall system.
A critical review on tablet disintegration - PubMed
Context: Tablet disintegration is an important factor for drug release and can be modified with excipients called tablet disintegrants. Tablet disintegrants act via different mechanisms and the efficacy of these excipients is influenced by various factors.
Tablet Disintegratability: Sensitivity of Superdisintegrants to ...
Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever.
Disintegrant is one of the most important components in a typical tablet dosage form. It is responsible for ensuring the break-up of the tablet matrix upon ingestion. Disintegrants act by different mechanisms, and a number of factors may affect their performance.
Recent Formulation Advances and Therapeutic Usefulness of …
Orally disintegrating or orally dispersible tablets (ODTs) are dosage forms that disintegrate or dissolve rapidly on contact with saliva. Certain ODTs that are formulated for sustained or controlled release have the ODT attribute of rapid disintegration but do …
Tablet Disintegration and Dispersion under In Vivo-like …
The analysis by 3D Tomo-LIF provides complementary and in-depth information on tablet disintegration and dispersion under defined and adjustable hydrodynamic conditions in the range of in vivo-like fluid velocities occurring most often in the human stomach in …
Advancing the understanding of the tablet disintegration …
Apr 1, 2021 · Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental quality attribute of immediate release tablets.
A Review of Disintegration Mechanisms and Measurement …
Mar 1, 2017 · A promising new technique to measure tablet disintegration is terahertz pulsed imaging (TPI). Most pharmaceutical excipients are transparent to terahertz radiation (far-infrared and sub-millimetre regime of the electromagnetic spectrum).